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Compound E

Potent γ-secretase inhibitor, 10 mg
SKU: SM-0002-0010



Product Description

Compound E is a potent γ-secretase inhibitor that specifically blocks β-amyloid-40 (IC50 of 0.24), β-amyloid-42 (IC50 of 0.37), and cleavage of the Notch domain (IC50 of 0.32). Compound E has been shown to promote the differentiation of embryonic stem cells (ESCs) to primitive neural precursors in addition to generating a self-renewing progenitor neuroepithelia stem cell population (Li, et al.) when combined with CHIR99021 (Cat. No. SM-0001-0010), SB431542 (Cat. No. SM-0009-0010), and hLIF. Forebrain GABA interneurons have also been derived from human pluripotent stem cells (PSCs) through the utilization of Compound E (Liu, et al.); additionally, it has shown promising effects in Alzheimer’s disease models using iPSC-derived neurons (Yagi, et al.).

Product Synonyms:
XXI, Compound E (secretase inhibitor), DuPont E, C-E, γ-secretase inhibitor XXI, Gamma-secretase inhibitor

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.



QTY 10 mg
Form Powder
Molecular Weight 490.5
Molecular Formula C27H24F2N4O3
Chemical Name N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
CAS Number 209986-17-4
Target γ-secretase 
Appearance White to off-white (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 100mM, for example:
10 mg/101.936 mL = 0.098 mg/mL = 0.2 mM
10 mg/20.387 mL = 0.491 mg/mL = 1 mM
10 mg/4.078 mL = 2.452 mg/mL = 5 mM
10 mg/2.0387 mL = 4.905 mg/mL = 10 mM
Storage Conditions Store at:
-20°C for 3 years
In solvent:
-80°C for 6 months
-20°C for 1 month
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.



  • Li, et al. 2011. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. PNAS. 108(20): 8299-304.
  • Liu, et al. 2013. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature Protocols. 8: 1670-1679.
  • Yagi, et al. 2011. Modeling familial Alzheimer’s disease with induced pluripotent stem cells. Human Molecular Genetics. 20(23): 4530-4539.


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