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Thiazovivin

Potent and selective inhibitor of Rho kinase (ROCK) activity, 10 mg
SKU: SM-0010-0010

Availability: In stock

$150.00

Description

Details

Product Description

Thiazovivin is a potent and selective inhibitor of Rho kinase (ROCK) activity, a key player in cytoskeletal contraction and rearrangement. As ROCK inhibition occurs, human embryonic stem cell survival increases through enhanced cell-ECM attachment via E-cadherin signaling (Xu, et al.), in addition to allowing for an environment for improved human iPSC induction from fibroblasts (Lin, et al.). The addition of Thiazovivin also creates more effective conditions for the reprogramming of cord blood mononuclear cells into iPSCs (Hu, et al.).

Product Synonyms:
Tzv, Rock inhibitor

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

Specifications

Specifications

QTY 10 mg
Form Powder
Molecular Weight 311.36
Molecular Formula C15H13N5OS
Chemical Name 4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-
CAS Number 1226056-71-8
Target ROCK
Appearance White to brown (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 40 mM, for example:
10 mg/32.117 mL = 0.311 mg/mL = 1 mM
10 mg/6.423 mL = 1.557 mg/mL = 5 mM
10 mg/3.212 mL = 3.113 mg/mL = 10 mM
10 mg/1.606 mL = 6.227 mg/mL = 20 mM
Storage Conditions Store at:
Powder:
-20°C for 3 years
4°C for 2 years

In solvent:
-80°C for 6 months
-20°C for 1 month
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

References

references

  • Hu, et al. 2011. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 117(14): 109-119.
  • Lin, et al. 2009. A chemical platform for improved induction of human iPSCs. Nature Methods. 6: 805-808.
  • Xu, et al. 2010. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. PNAS. 107(18): 8129-8134.

Documentation

Materials Safety Data Sheet

Technical Data Sheet

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