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XAV939

Tankyrase (TNKS) inhibitor, 10 mg
SKU: SM-0012-0010

Availability: In stock

$75.00

Description

Details

Product Description

XAV939 is a tankyrase (TNKS) inhibitor, most specifically for TNKS1 (IC50 of 5nM) and TNKS2 (IC50 of 2nM) (Haikarainen, et al.), in turn indirectly inhibiting downstream Wnt/β-catenin signaling (Huang, et al.). XAV939 has been shown to be an efficient additive in the derivation of functional neurons from human pluripotent stem cells (PSCs) when combined with other small molecules including LDN193189 (Cat. No. SM-0005-0010) and SB431542 (Cat. No. SM-0009-0010) (Qi, et al.). Additionally, XAV939 allows for the enhanced differentiation of PSCs into cardiomyocytes (Minami, et al.).

Product Synonyms:
XAV-939, XAV 939

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

Specifications

Specifications

QTY 10 mg
Form Powder
Molecular Weight 312.31
Molecular Formula C14H11F3N2OS
Chemical Name 4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-
CAS Number 284028-89-3
Target β-catenin; PARP
Appearance White to off-white (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 20 mM, for example:
10 mg/160.097 mL = 0.311 mg/mL = 0.2 mM
10 mg/32.020 mL = 1.557 mg/mL = 1 mM
10 mg/16.010 mL = 3.113 mg/mL = 2 mM
10 mg/3.202 mL = 6.227 mg/mL = 10 mM
Storage Conditions Store at:
Powder:
-20°C for 3 years
4°C for 2 years

In solvent:
-80°C for 6 months
-20°C for 1 month
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

References

references

  • Haikarainen, et al. (2014). Tankyrases: structure, function, and therapeutic implications in cancer. 20: 6472-6488.
  • Huang, et al. 2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature. 461(7264) :614-620.
  • Minami, et al. 2012. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Reports 2(5): 1448-1460.
  • Qi, et al. 2017. Combined small-molecule inhibition accelerations the derivation of functional cortical neurons from human pluripotent stem cells. Nature Biotechnology 35(2): 154-163.

Documentation

Materials Safety Data Sheet

Technical Data Sheet

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