Description
Details
Product Description
Compound E is a potent γ-secretase inhibitor that specifically blocks β-amyloid-40 (IC50 of 0.24), β-amyloid-42 (IC50 of 0.37), and cleavage of the Notch domain (IC50 of 0.32). Compound E has been shown to promote the differentiation of embryonic stem cells (ESCs) to primitive neural precursors in addition to generating a self-renewing progenitor neuroepithelia stem cell population (Li, et al.) when combined with CHIR99021 (Cat. No. SM-0001-0010), SB431542 (Cat. No. SM-0009-0010), and hLIF. Forebrain GABA interneurons have also been derived from human pluripotent stem cells (PSCs) through the utilization of Compound E (Liu, et al.); additionally, it has shown promising effects in Alzheimer’s disease models using iPSC-derived neurons (Yagi, et al.).Product Synonyms:
XXI, Compound E (secretase inhibitor), DuPont E, C-E, γ-secretase inhibitor XXI, Gamma-secretase inhibitorConstructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.
Specifications
Specifications
| QTY | 10 mg |
|---|---|
| Form | Powder |
| Molecular Weight | 490.5 |
| Molecular Formula | C27H24F2N4O3 |
| Chemical Name | N-[(1S)-2-[[(3S)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| CAS Number | 209986-17-4 |
| Target | γ-secretase |
| Appearance | White to off-white (Solid) |
| Purity | ≥95% by LCMS |
| Solubility and Reconstitution | Soluble in DMSO up to 100mM, for example: 10 mg/101.936 mL = 0.098 mg/mL = 0.2 mM 10 mg/20.387 mL = 0.491 mg/mL = 1 mM 10 mg/4.078 mL = 2.452 mg/mL = 5 mM 10 mg/2.0387 mL = 4.905 mg/mL = 10 mM |
| Storage Conditions | Store at: Powder: -20°C for 3 years In solvent: -80°C for 6 months -20°C for 1 month |
| Legal | This product is for Research Use Only and is not intended for therapeutic or diagnostic use. |
References
references
- Li, et al. 2011. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. PNAS. 108(20): 8299-304.
- Liu, et al. 2013. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature Protocols. 8: 1670-1679.
- Yagi, et al. 2011. Modeling familial Alzheimer’s disease with induced pluripotent stem cells. Human Molecular Genetics. 20(23): 4530-4539.
Documentation
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