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Triiodothyronine Salt

Analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1), 500 mg
SKU: SM-0011-0500

Availability: In stock

$150.00

Description

Details

Product Description

Triiodothyronine Salt (or Liothyronine sodium/3,3’,5-Triiodo-L-thyronine sodium) is an analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1). This binding, in turn, regulates functions such as growth, metabolic activity, and differentiation (Bhat, et al.). Triiodothyronine Salt has been shown to promote enhanced maturation of cardiomyocyte populations, to the extent that beating cardiomyocytes may be maintained for up to six months (Burridge, et al.), in addition to playing a role in the induction of pluripotent stem cells from human keratinocytes (Aasen & Belmonte).

Product Synonyms:
Liothyronine Sodium, 3,3’,5-Triiodo-L-thyronine sodium, T3 Sodium Salt, 3,3',5-Triiodothyronine, Liothyronine, T3 Thyroid Hormone, Triiodothyronine

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

Specifications

Specifications

QTY 10 mg
Form Powder
Molecular Weight 672.96
Molecular Formula C15H11I3NNaO4
Chemical Name L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, sodium salt (1:1)
CAS Number 55-06-1
Target Thyroid Hormone Receptor (TRβ1)
Appearance Off-white to gray (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 50 mM, for example:
500 mg/148.597 mL = 3.365 mg/mL = 5 mM
500 mg/74.299 mL = 6.730 mg/mL = 10 mM
500 mg/37.149 mL = 13.459 mg/mL = 20 mM
500 mg/14.860 mL = 33.647 mg/mL = 50 mM
Storage Conditions Store at:
Powder:
-20°C for 3 years
4°C for 2 years

In solvent:
-80°C for 6 months
-20°C for 1 month
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

References

references

  • Aasen & Belmonte. 2010. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols. 5: 371-382.
  • Bhat, et al. 1993. Conformational changes of human β1 thyroid hormone receptor induced by binding of 3,3’,5-Triiodo-L-thyronine. BiochemBiophys Res Commun. 195(1): 385-392.
  • Burridge, et al. 2015. Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells. Curr Protoc Hum Genet. 87(1): 1-15.

Documentation

Materials Safety Data Sheet

Technical Data Sheet

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