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Retinoic Acid

Acts as a ligand for nuclear retinoic acid receptors (RARs, specifically RARα/β/γ), 500 mg
SKU: SM-0007-0500

Availability: In stock

$75.00

Description

Details

Product Description

Retinoic Acid (all-trans) is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors (RARs, specifically RARα/β/γ) with an IC50 of 14nM and has a major effect on the differentiation and patterning of stem cells, and therefore in the development process (Rhinn & Dolle). In the process of differentiating mouse embryonic stem cells (ESCs), Retinoic Acid has been shown to promote the growth of glial cells and functional neurons in culture (Fraichard, et al.). Furthermore, Retinoic Acid has played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells when combined with CHIR99021 (Cat. No. SM-0001-0010), SANT-1 (Cat. No. SM-0008-0010), Y27632 (Cat. No. SM-0013-0010), Compound E (Cat. No. SM-0002-0010), RepSox (Cat. No. SM-0006-0010), Triiodothyronine Salt (Cat. No. SM-0011-0500), and other growth factors (Pagliuca, et al.).

Product Synonyms:
Retinoic acid (AT), Retinoic acid (All-trans), All-trans retinoic acid (ATRA), NSC 122758, Trans retinoic acid, Tretinoin, Vitamin A acid, RA

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

Specifications

Specifications

QTY 10 mg
Form Powder
Molecular Weight 300.44
Molecular Formula C20H28O2
Chemical Name (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
CAS Number 302-79-4
Target RAR/RXR; PPAR; Endogenous Metabolite
Appearance Light yellow to yellow (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 25 mM and Ethanol up to 2 mM, for example:
500 mg/1664.2 mL = 0.300 mg/mL = 1 mM
500 mg/832.113 mL = 0.601 mg/mL = 2 mM
500 mg/166.423 mL = 3.004 mg/mL = 10 mM
500 mg/83.211 mL = 6.009 mg/mL = 20 mM
Storage Conditions Store at:
4°C for 2 years and protect from light
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

References

references

  • Fraichard, et al. 1995. In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J of Cell Science. 108: 3181-3188.
  • Pagliuca, et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159: 428-439.
  • Rhinn & Dolle. 2012. Retinoic acid signaling during development. Development. 139: 843-858.

Documentation

Materials Safety Data Sheet

Technical Data Sheet

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