RepSox

Potent and selective inhibitor of the TGF-β type 1 receptor, 10 mg
SKU: SM-0006-0010

Availability: In stock

$125.00

Description

Details

Product Description

RepSox is a potent and selective inhibitor of the TGF-β type 1 receptor (TGFβRI)/ALK5 that exhibits cell permeability and specifically inhibits ALK5 autophosphorylation with IC50 of 4 nM. When used in conjunction with CHIR99021 (Cat. No. SM-0001-0010), LDN193189 (Cat. No. SM-0005-0010), and Y27632 (Cat. No. SM-0013-0010), among others, RepSox aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.). RepSox has also been shown to contribute to the reprogramming of mouse embryonic fibroblasts to iPSCs (Subramanyam, et al.), in addition to the induction of human fibroblasts into neuronal cells for research on Alzheimer’s disease (Hu, et al).

Product Synonyms:
ALK5 inhibitor II, ALK5 Inhibitor, ALK5i, E-616452, SJN2511

Constructed from renowned protocols, Biological Industries' selection of small molecules will streamline workflows for research in diabetes, neural disorders, and cardiovascular disease.

Specifications

Specifications

QTY 10 mg
Form Powder
Molecular Weight 287.32
Molecular Formula C17H13N5
Chemical Name 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
CAS Number 446859-33-2
Target TGF-β Receptor
Appearance Light yellow to yellow (Solid)
Purity ≥95% by LCMS
Solubility and Reconstitution Soluble in DMSO up to 100 mM, for example:
10 mg/34.804 mL = 0.287 mg/mL = 1 mM
10 mg/6.961 mL = 1.437 mg/mL = 5 mM
10 mg/3.480 mL = 2.874 mg/mL = 10 mM
10 mg/1.740 mL = 5.747 mg/mL = 20 mM
Storage Conditions Store at:
Powder:
-20°C for 3 years
4°C for 2 years

In solvent:
-80°C for 6 months
-20°C for 1 month
Legal This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

References

references

  • Hu, et al. 2015. Direct conversion of normal and Alzheimer’s disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell. 17(2): 204-212.
  • Pagliuca, et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159: 428-439.
  • Subramanyam, et al. 2011. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotechnology. 29:443-448.

Documentation

Materials Safety Data Sheet

Technical Data Sheet

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