Cardiovascular Research

As the leading cause of death, globally, cardiovascular disease warrants an immense amount of research into potential treatment options. Stem cell-based therapies hold great promise in the possibility of regenerating functional cardiac tissue following myocardial infarction. Noor, et al. (2019) utilized cardiomyocyte differentiation protocols for hiPSCs created by Edri, et al. (2018) and Lian, et al. (2012) (incorporating small molecules such as IWP-2, IWP-4, and CHIR99021) for the creation of three-dimensional vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models.

7 Item(s)

per page

  • CHIR99021

    Highly potent inhibitor of GSK3α and GSK3β. Learn More

  • IWP-2

    Inhibitor of WNT Production-2, 10 mg Learn More

  • IWP-4

    Inhibitor of WNT Production-4, 5 mg Learn More

  • SB431542

    Highly-potent and -selective inhibitor of the TGF-β type I receptor, 10 mg Learn More

  • Triiodothyronine Salt

    Analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1), 500 mg Learn More

  • XAV939

    Tankyrase (TNKS) inhibitor, 10 mg Learn More

  • SANT-1

    Potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, 10 mg Learn More

7 Item(s)

per page