Description
Details
Product Overview:
Faster growth rates and stronger cell yields
MSC NutriStem® XF Medium is a defined, serum-free, xeno-free culture medium designed for optimal growth and expansion of human mesenchymal stem/stromal cells (hMSC) derived from a variety of sources, including bone marrow (BM-MSC), adipose tissue (AT-MSC) and umbilical cord matrix (UC-MSC). MSC NutriStem® XF Medium supports long-term growth of hMSC while maintaining their self-renewal and multi-lineage differentiation potential.
hMSCs cultured in MSC NutriStem XF Medium show superior proliferation and self-renewal potential in comparison to serum-containing media and other commercial serum-free media. In addition, hMSCs maintain their proper fibroblast-like cell morphology, tri-lineage differentiation potential, and demonstrate normal hMSC marker profiles, and karyotypic stability over long-term culture.
Key advantages
- Serum-free, xeno-free, defined culture system
- Superior cell growth compared to serum-containing media
- Supports long-term growth and self-renewal of hMSCs from multiple sources
- Consistent, reliable MSC cultures
- Suitable for the harvest of high quality exosomes (EVs) for future clinical applications
- Eliminates the need to spend time and money pre-qualifying FBS lots
- Manufactured under cGMP
- FDA Drug Master File (DMF) available
Cells cultured in serum-containing medium do not require an adaptation phase when transitioning to serum-free MSC NutriStem® XF Medium.
Sample Data
Initial isolation
Figure: Human mesenchymal stem cells were initially isolated from Wharton's jelly (left image) and placenta (right image) using MSC NutriStem® XF on pre-coated plates with MSC Attachment Solution (cat. no. 05-752-1). High number of hMSC was obtained.
Proliferation
Figure: MSC NutriStem® XF promotes excellent proliferation of hMSC from a variety of sources while maintaining normal fibroblast-like, spindle shape cell morphology.
Self-renewal potential
Figure: hMSC-BM and hMSC-AT were expanded in MSC NutriStem® XF for 3-5 passages prior to 14 days of CFU-F assay. Colonies were stained with 0.5% crystal violet (x100). The cells maintain their self-renewal potential.
Differentiation potential
Figure: hMSC-BM (top panel) and hMSC-AT (bottom panel) expanded in MSC NutriStem® XF for 3-5 passages prior to trilineage differentiation. Representative images of stained adipocytes (Oil Red O), osteocytes (Alizarin Red) and chondrocytes (Alcian Blue). The cells maintain their multilineage differentiation potential.
Specifications
Specifications
Form | Liquid |
---|---|
Brand | NutriStem® |
Quality Control | MSC NutriStem® XF Medium is application-tested and validated for optimal maintenance and expansion of undifferentiated hMSCs, while maintaining their multi-lineage differentiation potential. |
Specifications | The complete mesenchymal stem cell culture media consists of two components: MSC NutriStem® XF Basal Medium (05-200-1) and MSC NutriStem® XF Supplement Mix (05-201-1). |
Instructions for Use | Storage and Stability
|
Legal | A Drug Master File (DMF) for MSC NutriStem® XF Medium is available. |
References
references
Clinical Trials and Applications
- B Mrozikiewicz-Rakowska et al. Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact. International Journal of Molecular Sciences. 2023; 24(2):1472. https://doi.org/10.3390/ijms24021472
- J. B. Kaczynski and J. K. Rzepka, Endometrial regeneration in Asherman's syndrome and endometrial atrophy using Wharton’s jelly-derived mesenchymal stem cells. Ginekologia Polska, 2022
- E. Atanasova, et al. Normal ex vivo mesenchymal stem cell function combined with abnormal immune profiles sets the stage for informative cell therapy trials in idiopathic pulmonary fibrosis patients. Stem Cell Res Ther, 2022. https://doi.org/10.1186/s13287-021-02692-0
- G. C. Blitzer, et al. A Pilot Study to Assess the Salivary Gland Regenerative Potential of Bone Marrow Mesenchymal Stromal Cells from Treated Head and Neck Cancer Patients. stem cell research & therapy, 2021, DOI:10.21203/rs.3.rs-965122/v1
- Y. Matsuo, et al. Isolation of adipose tissue-derived stem cells by direct membrane migration and expansion for clinical application. Human Cell (2021). https://doi.org/10.1007/s13577-021-00505-3
- T. Iwanaka, et al. A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment. Stem Cell Res Ther 11, 134 (2020). https://doi.org/10.1186/s13287-020-01630-w
- V.T. Hoang, et al. Expansion of Human Mesenchymal Stromal/Stem Cells Using Standardized Xeno-Free, Serum-Free Culture Condition blood,Volume 134, Issue Supplement_1, November 13 2019, https://doi.org/10.1182/blood-2019-132140
- C. Bozkurt, et al. The Use of Allogeneic Mesenchymal Stem Cells in Childhood Steroid-Resistant Acute Graft-Versus-Host Disease: A Retrospective Study of a Single-Center Experience tjh, 2019, 2019.0090 ;36:186-192
- D. Ben-David, et al. Autologous cell-coated particles for the treatment of segmental bone defects-a new cell therapy approach Journal of Orthopaedic Surgery and Research, volume 14, Article number: 198 (2019)
- L.A McIntyre et. al. Cellular Immunotherapy for Septic Shock. A Phase I Clinical Trial. American Journal of Respiratory and Critical Care Medicine, Vol. 197, No. 3, 2018
- K. Schlosser et al. Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Critical Care Medicine, doi: 10.1097/CCM.0000000000003657
Extracellular Vesicles and Exosomes
- R. Kou et al., Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: A nano-based investigation. Environmental Research, 2023
- C. Pezzana et al. Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium. Biomaterials, 2022
- M. Wolf et al. A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation. J Extracell Vesicles. 2022
- L. Xiang, et. al. Exosomes from human umbilical cord mesenchymal stem cells inhibit ROS production and cell apoptosis in human articular chondrocytes via the miR-100-5p/NOX4 axis. July 2021, Cell Biology International. https://doi.org/10.1002/cbin.11657
- T. Lyu, et. al. Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4. Exp Hematol Oncol 10, 24 (2021). https://doi.org/10.1186/s40164-021-00220-7
- M. A. Skylar-Scott, et al. Biomanufacturing oforgan-specific tissues withhigh cellular density andembedded vascular channels. Sci. Adv. 2019.
- Y. Li, et al. Mesenchymal Stem Cells and Acelluar Products Attenuate Murine Induced Colitis. Stem Cell Research & Therapy. 03 Sep, 2020 DOI:10.21203/rs.3.rs-65529/v1
- K. Narbute, et al. Time‑Dependent Memory and Gait Improvement by Intranasally‑Administered Extracellular Vesicles in Parkinson’s Disease Model Rats. Cellular and Molecular Neurobiology, 5 May 2020 https://doi.org/10.1007/s10571-020-00865-8
- X. Wang, et al. Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces Biomaterials, 24 October 2019, https://doi.org/10.1016/j.biomaterials.2019.119571
- J.W Li et al. Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5pEuropean Journal of Pharmacology, 2019
- Z. Zhu et al. Exosomes derived from human umbilical cord mesenchymal stem cells accelerate growth of VK2 vaginal epithelial cells through MicroRNAs in vitro. Human Reproduction, dey344, https://doi.org/10.1093/humrep/dey344, 2018
- T.C. Peak et al. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells. Biochemical and Biophysical Research Communications, Volume 499, Issue 4, 23 May 2018, Pages 1004-1010
- A. Jarmalavičiūtė et al., Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis. Cytotherapy, 2015
- U Pivoraitė et. al., Exosomes from Human Dental Pulp Stem Cells Suppress Carrageenan-Induced Acute Inflammation in Mice. Inflammation, April 2015
- K. Narbute et al. Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improve Motor Symptoms and Normalize Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats. STEM CELLS TRANSLATIONAL MEDICINE, pp. 1-10, 2019
- U. Jonavičė et al. Extracellular vesicles can act as a potent immunomodulators of human microglial cells. Journal of Tissue Engineering and Regenerative Medicine, 2019
- S. Bobis-Wozowicz et al. Diverse impact of xeno-free conditions on biological and regenerative properties of hUC-MSCs and their extracellular vesicles. Journal of Molecular Medicine, 2016
- M.Pokrywczynska et al., Transdifferentiation of Bone Marrow Mesenchymal Stem Cells into the Islet-Like Cells: the Role of Extracellular Matrix Proteins. Archivum Immunologiae et Therapiae Experimentalis, May 2015
Publications
- I. Szabłowska-Gadomska et al. Microbiological Aspects of Pharmaceutical Manufacturing of Adipose-Derived Stem Cell-Based Medicinal Products. Cells. 2023; 12(5):680. https://doi.org/10.3390/cells12050680
- B. Mrozikiewicz-Rakowska et al. Allogenic Adipose-Derived Stem Cells in Diabetic Foot Ulcer Treatment: Clinical Effectiveness, Safety, Survival in the Wound Site, and Proteomic Impact. International Journal of Molecular Sciences, 2023
- Y. Xie et al. Promotion effect of apical tooth germ cell-conditioned medium on osteoblastic differentiation of periodontal ligament stem cells through regulating miR-146a-5p. BMC Oral Health 22, 541 (2022)
- M. Machour et al. Print-and-Grow within a Novel Support Material for 3D Bioprinting and Post-Printing Tissue Growth. Advanced Science, 2022
- V.P. Mantripragada and G.F. Muschler Improved biological performance of human cartilage-derived progenitors in platelet lysate xenofree media in comparison to fetal bovine serum media. Current Research in Translational Medicine, 2022
- S. Cai et al. Single-cell RNA sequencing reveals the potential mechanism of heterogeneity of immunomodulatory properties of foreskin and umbilical cord mesenchymal stromal cells. Cell & Bioscience volume 12, Article number: 115 (2022)
- S. Sonoda et al. Protocol to generate xenogeneic-free/serum-free human dental pulp stem cells. STAR Protocols, 2022
- F. Yano et al. Effects of conditioned medium obtained from human adipose-derived stem cells on skin inflammation. Regenerative Therapy, 2022
- Y. Tan et al.HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis. Cell Death & Disease, 2022
- L. Souza-Moreira, et al. Poly(I:C) enhances mesenchymal stem cell control of myeloid cells from COVID-19 patients. iScience, 2022
- D. Murata, et al. Osteochondral regeneration of the femoral medial condyle by using a scaffold-free 3D construct of synovial membrane-derived mesenchymal stem cells in horses. BMC Vet Res, 2022. https://doi.org/10.1186/s12917-021-03126-y
- R. Vaka, et al. Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury. Stem Cell Res Ther, 2022 https://doi.org/10.1186/s13287-021-02699-7
- S. Landau, et al. Human-engineered auricular reconstruction (hEAR) by 3D-printed molding with human-derived auricular and costal chondrocytes and adipose-derived mesenchymal stem cells. Biofabrication, 2021. https://iopscience.iop.org/article/10.1088/1758-5090/ac3b91
- P. Vigneault, et al. Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection. Nat Commun, 2021. https://doi.org/10.1038/s41467-021-25180-8
- F. K. Touani, et al. Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells. Stem Cells International 2021 https://doi.org/10.1155/2021/6663467
- F. Mahyudin, et al. The Escalation of Osteosarcoma Stem Cells Apoptosis After the Co-Cultivation of Peripheral Blood Mononuclear Cells Sensitized with Mesenchymal Stem Cells Secretome and Colony Stimulating Factor-2 in vitro. J Blood Med. 2021. https://doi.org/10.2147/JBM.S305566
- A. Tait, et al. GMP compliant isolation of mucosal epithelial cells and fibroblasts from biopsy samples for clinical tissue engineering. Sci Rep 11, 12392 (2021). https://doi.org/10.1038/s41598-021-91939-0
- A. Ścieżyńska,et. al. Influence of Hypothermic Storage Fluids on Mesenchymal Stem Cell Stability: A Comprehensive Review and Personal Experience. Cells 2021, https://doi.org/10.3390/cells10051043
- I. Nikolits, Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells. Cells, 2021,10, 886. https://doi.org/10.3390/cells10040886
- S. Bhat, et al. Expansion and characterization of bone marrow derived human mesenchymal stromal cells in serum-free conditions. Sci Rep 11, 3403 (2021). https://doi.org/10.1038/s41598-021-83088-1
- M.G. Svahn, ALLOGENEIC COMPOSITION. US Patent App. 16/969,558, 2021
- G. G. Ying Chiew, et al. Optimizing Large-scale Expansion of Mesenchymal Stem Cells in 3D Tide Motion Bioreactors. Esco Aster poster publication, 2019.
- N. Aydoğdu, et al. Isolation, Culture, Cryopreservation, and Preparation of Skin-Derived Fibroblasts as a Final Cellular Product Under Good Manufacturing Practice–Compliant Conditions. Methods in Molecular Biology. (2020) Springer, New York, NY. https://doi.org/10.1007/7651_2020_333
- Jeriha J., et al. mRNA-Based Reprogramming Under Xeno-Free and Feeder-Free Conditions. Methods in Molecular Biology, 22 June 2020. DOIhttps://doi.org/10.1007/7651_2020_302
- S. Suresh,et al. A nanocomposite hydrogel delivery system for mesenchymal stromal cell secretome. Stem Cell Res Ther 11, 205 (2020). https://doi.org/10.1186/s13287-020-01712-9
- V.Alonso-Camino & B.Mirsch, Development of standard protocol for the cGMP production of human mesenchymal stem/stromal cells from different source tissues. Cytotherapy Volume 22, Issue 5, Supplement, May 2020, Page SS65-S66, https://doi.org/10.1016/j.jcyt.2020.03.099
- A. López Fernández, et al. Successful scale up expansion of Wharton's jelly mesenchymal stromal cells in different commercial xeno-free and serum-free media. Cytotherapy Volume 22, Issue 5, Supplement, May 2020, Page S94, https://doi.org/10.1016/j.jcyt.2020.03.162
- B. Brinkhof, et al. ALCAM (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation. Gene: X 14 March 2020, 100031, https://doi.org/10.1016/j.gene.2020.100031
- Guan, S., et al. Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model. EJNMMI Res 10, 13 (2020). https://doi.org/10.1186/s13550-020-0597-3
- S. Mount et. al. Physiologic expansion of human heartderived cells enhances therapeutic repair of injured myocardium. Stem Cell Research & Therapy (2019) 10:316
- S. R. Cohen, et al. Cellular Optimization of Nanofat: Comparison of Two Nanofat Processing Devices in Terms of Cell Count and Viability Aesthetic Surgery Journal Open Forum, https://doi.org/10.1093/asjof/ojz028 Published: 30 September 2019
- D. Boruczkowski, et al. Wharton’s Jelly Mesenchymal Stem Cell Administration Improves Quality of Life and Self-Sufficiency in Children with Cerebral Palsy: Results from a Retrospective Study Hindawi Stem Cells International Volume 2019, Article ID 7402151, 13 pages, https://doi.org/10.1155/2019/7402151
- G.Sagaradze, et al. Conditioned Medium from Human Mesenchymal Stromal Cells: Towards the Clinical Translation Int.J.Mol.Sci. 2019, 20, 1656; doi:10.3390/ijms20071656
- M.Valitsky et al. Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Experimental Autoimmune Encephalomyelitis Int.J.Mol. Sci., 2019, 20(7),1793;https://doi.org/10.3390/ijms20071793
- Y. Ben et al. STABILIZED AMORPHOUS CALCIUM CARBONATE FOR TREATMENT OF NEUROLOGICAL , MUSCULAR AND INFERTILITY DISEASES OR CONDITIONS . US Patent App. 16/069,762, 2019
- J. Favaloro et al. EVALUATION OF HUMAN PLATELET LYSATE (HPL) AS A SUBSTITUTE FOR FOETAL BOVINE SERUM (FBS) AND RECOMBINANT PROTEINS FOR THE GROWTH AND MAINTENANCE OF BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS (BM-MSC). Cytotherapy, Volume 21, Issue 5, Supplement, May 2019, Pages S84-S85
- G. Chew et al. TIDE MOTION BIOREACTORS FOR LARGE-SCALE CULTIVATION AND EXPANSION OF HUMAN MESENCHYMAL STEM CELLS. Cytotherapy, Volume 21, Issue 5, Supplement, May 2019, Page S85
- V. Alonso-Camino and B. Mirsch, Rapid expansion of Mesenchymal Stem/Stromal Cells using optimized media supplemented with human platelet lysate PLTMax® or PLTGold®, suitable for cGMP expansion at large scale. Cytotherapy, Volume 21, Issue 5, Supplement, May 2019, Page S85
- S. Pang et al. DISSECTING THE MOLECULAR PATHWAYS OF APOPTOSIS IN MESENCHYMAL STROMAL CELL THERAPY. Cytotherapy, Volume 21, Issue 5, Supplement, May 2019, Page S85
- M. Valitsky et al. Cerebrospinal Fluid (CSF) Exchange with Artificial CSF Enriched with Mesenchymal Stem Cell Secretions Ameliorates Experimental Autoimmune Encephalomyelitis. Int. J. Mol. Sci. 2019, 20(7), 1793; https://doi.org/10.3390/ijms20071793
- A. Yamasaki et al. Osteochondral regeneration using constructs of mesenchymal stem cells made by bio three‐dimensional printing in mini‐pigs. Journal of Orthopaedic Research, 2018
- Vu N.B., Le P.TB., Truong N.C., Van Pham P. (2018) Off-the-Shelf Mesenchymal Stem Cell Technology. In: Pham P. (eds) Stem Cell Drugs - A New Generation of Biopharmaceuticals. Stem Cells in Clinical Applications. Springer, Cham
- J.K. Ledwon et al. Osteogenic Differentiation Of Msc As A Model Study Of The Postnatal Progressive Crouzon Syndrome. Plastic and Reconstructive Surgery - Global Open. 6(4S):116, APR 2018
- D.Lisini et al. Adipose tissue-derived mesenchymal stromal cells for clinical application: An efficient isolation approach. Current Research in Translational Medicine, https://doi.org/10.1016/j.retram.2018.06.002
- S. Khan et al. cGMP-Compatible Large-Scale Production of Mesenchymal Stem Cells (MSCs) In Xeno- and Serum-Free Media for Allogeneic Cell Therapies. Cytotherapy,Volume 20, Issue 5, Supplement, Page S42, 2018
- A.C. Volz and P.J. Kluger, Completely serum-free and chemically defined adipocyte development and maintenance.Cytotheraoy, April 2018 Volume 20, Issue 4, Pages 576–588
- C. Elseberg et al. The Challenge of Human Mesenchymal Stromal Cell Expansion: Current and Prospective Answers. New Insights into Cell Culture Technology, Dr. Sivakumar Joghi Thatha Gowder (Ed.), InTech.
- C. Ceccaldi et al. Optimization of Injectable Thermosensitive Scaffolds with Enhanced Mechanical Properties for Cell Therapy. Macromolecular Bioscience, 2017
- D. Boruczkowski et al.Third-party Wharton’s jelly mesenchymal stem cells for treatment of steroid-resistant acute and chronic graft-versus-host disease: a report of 10 cases. Turkish Journal of Biology, 40: 493-500, 2016
- Jianxia H. et al. Long term effect and safety of Wharton's jelly-derived mesenchymal stem cells on type 2 diabetes. Experimental and Therapeutic Medicine, Volume 12 Issue 3, 2016
- L. Berger et al. Tumor Specific Recruitment and Reprogramming of Mesenchymal Stem Cells in TumorigenesisSTEM CELLS Volume 34, Issue 4, Version of Record online: 31 DEC 2015
- K.Y. Tan et al. Serum-free media formulations are cell line–specific and require optimization for microcarrier culture. Cytotherapy, 2015
- Cai, Zhen, et al. Chondrogenesis of Human Adipose-Derived Stem Cells by In Vivo Co-graft with Auricular Chondrocytes from Microtia. Aesthetic plastic surgery 39.3 (2015): 431-439.
- S.H. Mei, et al. Isolation and large-scale expansion of bone marrow-derived mesenchymal stem cells with serum-free media under GMP-compliance. Cytotherapy, Volume 16, Issue 4, Supplement , Page S111, April 2014
- Mira Genser-Nir et al. Toward a serum-free, xeno-free culture system for optimal growth and expansion of hMSC suited to therapeutic applications. BMC Proc. 2013; 7(Suppl 6): P6.
- McVey, Mark John, et al. Microparticles as biomarkers of lung disease-enumeration in biological fluids using lipid bilayer microspheres. American Journal of Physiology-Lung Cellular and Molecular Physiology (2016): ajplung-00369.
- Y. Lopez, et al. Identification of Optimal Conditions For Generating MSCs For Preclinical Testing: Comparison of Three Commercial Serum-Free Media And Low-Serum Growth Medium. From 18th ISCT Annual Meeting, Seattle, USA, 2012.
- R. D. Foster et al. GorodetskyFibrin microbeads loaded with mesenchymal cells support their long-term survival while sealed at room temperature.Tissue Eng Part C Methods2011TISSUE ENGINEERING: Part C, Volume 17, Number 7, 2011
Documentation
Materials Safety Data Sheet
- MSC NutriStem® XF Basal Medium (MSDS)
- MSC NutriStem® XF Supplement Mix (MSDS)
- MSC NutriStem® XF Basal Medium, without Phenol Red (MSDS)
Manuals and Protocols
- MSC NutriStem® XF Medium Instructions for Use
- Thawing Human MSCs in NutriStem® MSC Medium and Human Platelet Lysate
- Passaging MSCs using NutriStem® MSC Medium and Human Platelet Lysate
- Cryopreservation of Human MSCs
Product Literature
- MSC NutriStem® XF Medium Product Sheet
- Application Note: Growing more cells: cGMP culture environments for high yield expansion of MSCs
- Sample Data: NutriStem® MSC Medium with PLTMax® or PLTGold® Human Platelet Lysate demonstrates superior expansion of MSCs
- Poster: A Xeno-Free Culture System for hMSC from Various Sources Suitable for Initial Isolation and Expansion Toward Clinical Applications
- Poster: A Unique Defined Pre-Coating - Free Culture Platform for Isolation and Expansion of hMSC Towards Clinical Applications
Blog Posts & Articles
- Blog: Top 5 Reasons to Use NutriStem® for Isolation and Growth of hMSCs (BioInformant)
- Blog: Facilitating the Use of MSCs for Regenerative Medicine Applications through Serum-Free, Xeno-Free Differentiation Media (BioInformant)
Frequently Asked Questions
Certificate of Analysis
COA's can be downloaded from Sartorius's Certificates Portal.
For certificates issued before November 15, 2021, please enter below the product lot number and click search.
Reviews
Customer Reviews (4)
- Quality and consistency cellsReview by Prof. Avner Yayon
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Quality - my cells love it!Review by Tony
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Quality - very efficientReview by Yasmin
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Quality - excellentReview by Jason
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Quality